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EPIDEM 2601 - MOLECULAR EPIDEMIOLOGY TOOLS & TECHNIQUESMinimum Credits: 3 Maximum Credits: 3 There is a steady stream of new methods and technologies entering the biomedical sciences that can be used to generate high-quality, quantitative data on the molecular and biochemical aspects of health and disease. There is tremendous value in applying these methods in epidemiologic studies to interrogate the molecular underpinnings of associations within populations, generate hypotheses on the mechanisms involved, to monitor the effects of interventions and to increase confidence in causal inferences. This course will be an opportunity for students to be exposed to methods for measuring the biologic processes that are relevant to DNA variation in populations, and to exposure effects that impact RNA and protein (and other molecule) expression. This course will go beyond the standard level of awareness of how to receive and analyze data from a laboratory. We will engage students in rigorous thought on how to pose questions on the underlying biology, conduct biomarker selection, design assays, and analyze and interpret data. We will spend ~50% of the time exposing students to hands-on experimentation at the laboratory bench. While, we will discuss 'omics' and high-dimensional methods in lectures, the hands-on work will be limited to single molecule analyses. Academic Career: Graduate Course Component: Lecture Grade Component: Grad Letter Grade Course Requirements: PREQ: EPIDEM 2600 and EPIDEM 2180 and EPIDEM 2185
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